Pathophysiology

Sepsis

Sepsis

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection.

Criteria (qSOFA)

  • Respiratory rate ≥ 22/min
  • Altered mentation (GCS < 15)
  • Systolic blood pressure ≤ 100 mmHg

Sepsis Bundle (1-Hour)

  • Measure lactate levels
  • Obtain blood cultures before starting antibiotics
  • Administer broad-spectrum antibiotics
  • Administer 30 mL/kg crystalloid for hypotension or lactate ≥ 4 mmol/L

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