Pathophysiology

Cirrhosis

Cirrhosis

Cirrhosis is the end-stage of chronic liver disease characterized by extensive fibrosis and nodule formation.

Complications

  • Portal hypertension leading to varices
  • Ascites due to low serum albumin
  • Hepatic encephalopathy from ammonia buildup
  • Coagulopathy due to impaired clotting factor production

Management

  • Administer lactulose for encephalopathy
  • Measure abdominal girth daily
  • Restrict sodium and protein intake
  • Avoid hepatotoxic meds like acetaminophen

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