Pharmacology

Opioid Analgesics

Opioid Analgesics

Opioids are potent analgesics used for moderate to severe pain, acting on CNS opioid receptors.

Safety and Assessment

  • Assess respiratory rate before and after administration.
  • Hold dose if respiratory rate is less than 12 breaths per minute.
  • Naloxone is the reversal agent for opioid-induced respiratory depression.
  • Monitor for constipation; initiate bowel regimen proactively.

Administration

  • Use caution in patients with head injuries (increased ICP risk).
  • Implement fall precautions, especially in older adults (orthostatic hypotension).
  • Evaluate pain effectiveness 30-60 minutes post-administration.

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