Anatomy & Physiology

Glucose Homeostasis

Glucose Homeostasis

Blood glucose regulation relies on the antagonistic effects of insulin and glucagon on the liver and peripheral tissues.

Regulatory Hormones

  • Insulin: Secreted by pancreatic beta cells; facilitates glucose uptake into cells and promotes glycogenesis.
  • Glucagon: Secreted by pancreatic alpha cells; stimulates glycogenolysis and gluconeogenesis in the liver.
  • Cortisol and Epinephrine: Counter-regulatory hormones that increase blood glucose during stress.

Clinical Monitoring

  • Monitor for hypoglycemia (sweating, tremors, confusion) when insulin levels are high.
  • Assess for hyperglycemia symptoms (polyuria, polydipsia, polyphagia) in diabetic patients.
  • Check HbA1c for long-term glycemic control assessment (previous 90-120 days).

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