Emergency Responses and Disaster Preparedness

Nerve Agent Exposure

Nerve Agent Exposure

Nerve agents (e.g., Sarin, VX) cause a cholinergic crisis via acetylcholinesterase inhibition.

SLUDGEM Syndrome

  • Salivation, Lacrimation, Urination, Defecation, GI distress, Emesis, Miosis (pinpoint pupils).
  • Excessive bronchial secretions lead to rapid airway obstruction.
  • Monitor for bradycardia and muscle fasciculations.

Pharmacological Treatment

  • Atropine: Primary drug for drying secretions and reversing bradycardia.
  • Pralidoxime: Reactivates acetylcholinesterase.
  • Benzodiazepines: Administer for seizure control.
  • Aggressive airway management and suctioning are essential.

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